Current Research
The goal of the Collins Lab is to integrate non-invasive imaging methods with experimental mechanics and computational modeling in order to develop clinically applicable tools to monitor bone integrity, fracture risk, and fracture healing in patients. Through this, the lab aims to better understand and model how the mechanobiological pathways in bone modulate its structure and physiology from cell to organ scale, and how diseases and treatments perturb this system. Currently, our lab works in the development of strain associated biomarkers and the biomechanical behavior of bones inmpacted by osteosarcoma.
Development of strain-associated biomarkers for precision medicine in delayed fracture healing
3D bioprinting, patient primary cells, micro-computed tomography imaging, gene expression, finite element analysis.
Investigate the effect of mixed sclerotic and osteolytic lesions on the biomechanical behavior of canine cadaver limbs with osteosarcoma using image-based finite element modeling
Magnetic resonance imaging, computed tomography imaging, mechanical testing, finite element analysis.
Research Partners
